Highly economical and direct amination of sp³ carbon using low-cost nickel pincer catalyst.

ABSTRACT: Developing more efficient routes to achieve C-N bond coupling is of great importance to industries ranging from products in pharmaceuticals and fertilizers to biomedical technologies and next-generation electroactive materials. Over the past decade, improvements in catalyst design have moved synthesis away from expensive metals to newer inexpensive C-N cross-coupling approaches via direct amine alkylation. For the first time, we report the use of an amide-based nickel pincer catalyst (1) for direct alkylation of amines via activation of sp³ C-H bonds. The reaction was accomplished using a 0.2 mol% catalyst and no additional activating agents other than the base. Upon optimization, it was determined that the ideal reaction conditions involved solvent dimethyl sulfox

SUBMITTER: Brandt A 

PROVIDER: S-EPMC8693581 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature