Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment.

ABSTRACT: Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia. Objective: The aim of this study was to explore the trajectories of cognitive decline in an MCI sample from a memory clinic, taking into consideration a perspective of isolated cognitive functions and based on NPS clusters, accounting for the different comorbid symptoms collected at their baseline visit. Methods: A total of 2,137 MCI patients were monitored over a 2.4-year period. Four clusters of NPS (i.e., Irritability, Apathy, Anxiety/Depression and Asymptomatic) were used to run linear mixed models to explore the interaction of cluster with time on cognitiv

SUBMITTER: Roberto N 

PROVIDER: S-EPMC8693625 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature