Decreased Intrinsic Neural Timescales in Mesial Temporal Lobe Epilepsy.

ABSTRACT: It is well established that epilepsy is characterized by the destruction of the information capacity of brain network and the interference with information processing in regions outside the epileptogenic focus. However, the potential mechanism remains poorly understood. In the current study, we applied a recently proposed approach on the basis of resting-state fMRI data to measure altered local neural dynamics in mesial temporal lobe epilepsy (mTLE), which represents how long neural information is stored in a local brain area and reflect an ability of information integration. Using resting-state-fMRI data recorded from 36 subjects with mTLE and 36 healthy controls, we calculated the intrinsic neural timescales (INT) of neural signals by summing the positive magnitude of the autocorrelation

SUBMITTER: Wang K 

PROVIDER: S-EPMC8693765 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature