Maternal Phthalates Exposure and Blood Pressure during and after Pregnancy in the PROGRESS Study.

ABSTRACT:

Background

Phthalate exposure is ubiquitous and may affect biological pathways related to regulators of blood pressure. Given the profound changes in vasculature during pregnancy, pregnant women may be particularly susceptible to the potential effects of phthalates on blood pressure.

Objectives

We examined associations of phthalate exposure during pregnancy with maternal blood pressure trajectories from mid-pregnancy through 72 months postpartum.

Methods

Women with singleton pregnancies delivering a live birth in Mexico City were enrolled during the second trimester (n=892). Spot urine samples from the second and third trimesters were analyzed for 15 phthalate metabolites. Blood pressure and covariate data were collected over nine visits through 72 months postpartum.

SUBMITTER: Wu H 

PROVIDER: S-EPMC8693773 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature