Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes.

ABSTRACT:

Introduction

Dogs with naturally occurring diabetes mellitus represent a potential model for human type 1 diabetes, yet significant knowledge voids exist in terms of the pathogenic mechanisms underlying the canine disorder. Untargeted metabolomic studies from a limited number of diabetic dogs identified similarities to humans with the disease.

Objective

To expand and validate earlier metabolomic studies, identify metabolites that differ consistently between diabetic and healthy dogs, and address whether certain metabolites might serve as disease biomarkers.

Methods

Untargeted metabolomic analysis via liquid chromatography-mass spectrometry was performed on serum from diabetic (n = 15) and control (n = 15) dogs. Results were combined with those of our previously publis

SUBMITTER: O'Kell AL 

PROVIDER: S-EPMC8693811 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature