Dataset Information

Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6.

ABSTRACT: Two new xanthones, oxisterigmatocystins J and K (1-2), and two new anthraquinones, versicolorins D and E (3-4), were isolated from solid cultures of the fungus Penicillium sp. DWS10-P-6, together with twelve known compounds (5-16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data. The cytotoxic activities of compounds 1-12 against HL-60, MDA-MB-231 and PC-3 cells were also evaluated. Compounds 4 and 5 showed significant cytotoxic activity against the HL-60 cell line with IC₅₀ values of 1.65 μM and 1.05 μM, respectively.

SUBMITTER: Wang YJ

PROVIDER: S-EPMC8693886 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Xanthones and anthraquinones from the soil fungus <i>Penicillium</i> sp. DWS10-P-6.

Wang Ya-Jing YJ Ma Nan N Liu Chun-Yue CY Feng Yi-Xuan YX Zhang Feng-Xiang FX Li Chang C Pei Yue-Hu YH

RSC advances 20210114 5

Two new xanthones, oxisterigmatocystins J and K (1-2), and two new anthraquinones, versicolorins D and E (3-4), were isolated from solid cultures of the fungus <i>Penicillium</i> sp. DWS10-P-6, together with twelve known compounds (5-16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data. The cytotoxic activities of compounds 1-12 against HL-60, MDA-MB-231 and PC-3 cells were also evaluated. Compounds 4 ...[more]

PMID: 35424208

Similar Datasets

Project description:The emergence of multiresistant bacteria and the shortage of antibacterials in the drug pipeline creates the need to search for novel agents. Evolution drives the optimization of the structure of marine natural products to act as antibacterial agents. Polyketides are a vast and structurally diverse family of compounds that have been isolated from different marine microorganisms. Within the different polyketides, benzophenones, diphenyl ethers, anthraquinones, and xanthones have shown promising antibacterial activity. In this work, a dataset of 246 marine polyketides has been identified. In order to characterize the chemical space occupied by these marine polyketides, molecular descriptors and fingerprints were calculated. Molecular descriptors were analyzed according to the scaffold, and principal component analysis was performed to identify the relationships among the different descriptors. Generally, the identified marine polyketides are unsaturated, water-insoluble compounds. Among the different polyketides, diphenyl ethers tend to be more lipophilic and non-polar than the remaining classes. Molecular fingerprints were used to group the polyketides according to their molecular similarity into clusters. A total of 76 clusters were obtained, with a loose threshold for the Butina clustering algorithm, highlighting the large structural diversity of the marine polyketides. The large structural diversity was also evidenced by the visualization trees map assembled using the tree map (TMAP) unsupervised machine-learning method. The available antibacterial activity data were examined in terms of bacterial strains, and the activity data were used to rank the compounds according to their antibacterial potential. This potential ranking was used to identify the most promising compounds (four compounds) which can inspire the development of new structural analogs with better potency and absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties.

Dataset Information

Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6.

Publications

Xanthones and anthraquinones from the soil fungus <i>Penicillium</i> sp. DWS10-P-6.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets