Modeling and analysis of the macronutrient signaling network in budding yeast.

ABSTRACT: Adaptive modulation of the global cellular growth state of unicellular organisms is crucial for their survival in fluctuating nutrient environments. Because these organisms must be able to respond reliably to ever varying and unpredictable nutritional conditions, their nutrient signaling networks must have a certain inbuilt robustness. In eukaryotes, such as the budding yeast Saccharomyces cerevisiae, distinct nutrient signals are relayed by specific plasma membrane receptors to signal transduction pathways that are interconnected in complex information-processing networks, which have been well characterized. However, the complexity of the signaling network confounds the interpretation of the overall regulatory "logic" of the control system. Here, we propose a literature-curated mol

SUBMITTER: Jalihal AP 

PROVIDER: S-EPMC8693975 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature