Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family.

ABSTRACT: We show that salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3'-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels. Simple structure-activity relationship studies reveal that the salacinol side-chain stereochemistry significantly influences binding to GH31 α-glucosidases.

SUBMITTER: Ishikawa F 

PROVIDER: S-EPMC8694024 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature