Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support.

ABSTRACT: In recent years, preparation of fully protected trinucleotide phosphoramidites as synthons for the codon-based synthesis of gene libraries as well as for the assembly of oligonucleotides from blockmers has gained much attention. We here describe the preparation of such trinucleotide synthons on a soluble support using a disulphide linker.

SUBMITTER: Suchsland R 

PROVIDER: S-EPMC8694130 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature