Analysis of an IncR Plasmid Carrying bla_NDM-1 Linked to an Azithromycin Resistance Region in Enterobacter hormaechei Involved in an Outbreak in Quebec.

ABSTRACT: In the context of a recent rise in prevalence of NDM-encoding carbapenemase-producing Enterobacterales (CPE) in the province of QC, Canada, the genetic environment of bla_NDM-1 was investigated. Three NDM-producing clinical isolates of Enterobacter hormaechei recovered from hospitalized patients involved in a putative outbreak were further characterized by whole-genome sequencing (WGS). Two isolates were confirmed by pulsed-field gel electrophoresis and WGS to be closely related. In addition to a ∼128 kb IncFII conjugative multidrug-resistance (MDR) plasmid, these isolates possessed a ∼45 kb mobilizable IncR MDR plasmid containing 2 MDR regions: a complex class 1 integron harboring bla_NDM-1 and 7 other AMR genes, and the IS26-mph(A)-mrx-mphR

SUBMITTER: Doualla-Bell F 

PROVIDER: S-EPMC8694144 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature