A phase II study of laser interstitial thermal therapy combined with doxorubicin in patients with recurrent glioblastoma.

ABSTRACT:

Background

The blood-brain barrier (BBB) is a major limiting factor for drug delivery in brain tumors. Laser interstitial thermal therapy (LITT) disrupts the peritumoral BBB. In this study, we examine survival in patients with recurrent glioblastoma (GBM) treated with LITT followed by low-dose doxorubicin, a potent anti-neoplastic drug with poor BBB permeability.

Methods

Forty-one patients with recurrent GBM were enrolled; thirty patients were evaluable. Participants underwent LITT followed by 6 weekly doxorubicin treatments starting within one week (Early Arm) or at 6-8 weeks (Late Arm) after LITT. The overall survival (OS), local progression-free survival (PFS), and any PFS were compared to historical controls treated with bevacizumab salvage therapy (n = 50) or LIT

SUBMITTER: Butt OH 

PROVIDER: S-EPMC8694207 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature