Homotopic functional connectivity disruptions in glioma patients are associated with tumor malignancy and overall survival.

ABSTRACT:

Background

Gliomas exhibit widespread bilateral functional connectivity (FC) alterations that may be associated with tumor grade. Limited studies have examined the connection-level mechanisms responsible for these effects. Given the typically strong FC observed between mirroring/homotopic brain regions in healthy subjects, we hypothesized that homotopic connectivity (HC) is altered in low-grade and high-grade glioma patients and the extent of disruption is associated with tumor grade and predictive of overall survival (OS) in a cohort of de novo high-grade glioma (World Health Organization [WHO] grade 4) patients.

Methods

We used a mirrored FC-derived cortical parcellation to extract blood-oxygen-level-dependent (BOLD) signals and to quantify FC differences between ho

SUBMITTER: Daniel AGS 

PROVIDER: S-EPMC8694208 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature