Reevaluating surgery and re-irradiation for locally recurrent pediatric ependymoma-a multi-institutional study.

ABSTRACT:

Background

The goal of this study was to evaluate extent of surgical resection, and timing and volume of re-irradiation, on survival for children with locally recurrent ependymoma.

Methods

Children with locally recurrent ependymoma treated with a second course of fractionated radiotherapy (RT2) from 6 North American cancer centers were reviewed. The index time was from the start of RT2 unless otherwise stated.

Results

Thirty-five patients were included in the study. The median doses for first radiation (RT1) and RT2 were 55.8 and 54 Gy, respectively. Median follow-up time was 5.6 years. Median overall survival (OS) for all patients from RT2 was 65 months. Gross total resection (GTR) was performed in 46% and 66% of patients prior to RT1 and RT2, respectively. GTR prior

SUBMITTER: Mak DY 

PROVIDER: S-EPMC8694210 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature