Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma.

ABSTRACT: The tumor microenvironment (TME) affects the biologic malignancy of clear cell renal cell carcinoma (ccRCC). The influence of the 5-methylcytosine (m⁵C) epigenetic modification on the TME is unknown. We comprehensively assessed m⁵C modification patterns of 860 ccRCC samples (training, testing, and real-world validation cohorts) based on 17 m⁵C regulators and systematically integrated the modification patterns with TME cell-infiltrating characterizations. Our results identified distinct m⁵C modification clusters with gradual levels of immune cell infiltration. The distinct m⁵C modification patterns differ in clinicopathological features, genetic heterogeneity, patient prognosis, and treatment responses of ccRCC. An elevated m⁵

SUBMITTER: Xu W 

PROVIDER: S-EPMC8694268 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature