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Reusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols.

ABSTRACT: A general cobalt-catalyzed N-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary, and tertiary amines including N-methylamines and selected drug molecules were conveniently prepared starting from inexpensive and easily accessible alcohols and amines or ammonia.

SUBMITTER: Ma Z

PROVIDER: S-EPMC8694384 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Reusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols.

Ma Zhuang Z Zhou Bei B Li Xinmin X Kadam Ravishankar G RG Gawande Manoj B MB Petr Martin M Zbořil Radek R Beller Matthias M Jagadeesh Rajenahally V RV

Chemical science 20211129 1

A general cobalt-catalyzed N-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary, and tertiary amines including ...[more]

PMID: 35059158

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