Enhancing the biological activity of polyoxometalate-peptide nano-fibrils by spacer design.

ABSTRACT: Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability.

SUBMITTER: Tagliavini V 

PROVIDER: S-EPMC8694496 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature