METTL1-m⁷ G-EGFR/EFEMP1 axis promotes the bladder cancer development.

ABSTRACT:

Background

The posttranscriptional modifications of transfer RNA (tRNA) are critical for all aspects of the tRNA function and have been implicated in the tumourigenesis and progression of many human cancers. By contrast, the biological functions of methyltransferase-like 1 (METTL1)-regulated m⁷ G tRNA modification in bladder cancer (BC) remain obscure.

Results

In this research, we show that METTL1 was highly expressed in BC, and its level was correlated with poor patient prognosis. Silencing METTL1 suppresses the proliferation, migration and invasion of BC cells in vitro and in vivo. Multi-omics analysis reveals that METTL1-mediated m⁷ G tRNA modification altered expression of certain target genes, including EGFR/EFEMP1. Mechanistically, METTL1 regulate

SUBMITTER: Ying X 

PROVIDER: S-EPMC8694502 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature