Niobium- and zirconium-catalyzed reactions of substituted 2 alkynylamines with Et₂Zn.

ABSTRACT: The NbCl₅-EtMgBr-catalyzed reaction of N,N-disubstituted 2-alkynylamines with Et₂Zn followed by hydrolysis or deuterolysis affords (2Z)-alkenylamines (reduction products of alkyne) in high yields. The reaction of N,N-disubstituted 2-alkynylamines with Et₂Zn catalyzed by the Cp₂ZrCl₂-EtMgBr system occurs as 2-zincoethylzincation, resulting, after deuterolysis or iodinolysis, in the regio- and stereoselective formation of the corresponding dideuterated and diiodinated 2-alkenylamine derivatives with a trisubstituted double bond. This study demonstrates the difference between the catalytic effects of NbCl₅ and Cp₂ZrCl₂ on the pathway of reaction of tertiary 2-alkynylamine

SUBMITTER: Kadikova RN 

PROVIDER: S-EPMC8694551 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature