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Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells.

ABSTRACT: [Figure: see text].

SUBMITTER: Sun Y

PROVIDER: S-EPMC8694622 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells.

Sun Yan Y Lin Xiaolin X Liu Bangdong B Zhang Yaxuan Y Li Wei W Zhang Sheng S He Falian F Tian Han H Zhu Xun X Liu Ximeng X Wu Jueheng J Cai Junchao J Li Mengfeng M

Science advances 20211222 52

Aging of hematopoietic stem cells (HSCs) directly contributes to dysfunction of hematopoietic and immune systems due to aging-associated alterations in HSC features. How the function of adult HSCs is regulated during aging so that relevant pathologic abnormalities may occur, however, remains incompletely understood. Here, we report that ATF4 deficiency provokes severe HSC defects with multifaceted aging-like phenotype via cell-autonomous mechanisms. <i>ATF4</i> deletion caused expansion of pheno ...[more]

PMID: 34936448

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