Transcriptional profiling of sequentially generated septal neuron fates.

ABSTRACT: The septum is a ventral forebrain structure known to regulate innate behaviors. During embryonic development, septal neurons are produced in multiple proliferative areas from neural progenitors following transcriptional programs that are still largely unknown. Here, we use a combination of single-cell RNA sequencing, histology, and genetic models to address how septal neuron diversity is established during neurogenesis. We find that the transcriptional profiles of septal progenitors change along neurogenesis, coinciding with the generation of distinct neuron types. We characterize the septal eminence, an anatomically distinct and transient proliferative zone composed of progenitors with distinctive molecular profiles, proliferative capacity, and fate potential compared to the rostral septa

SUBMITTER: Turrero Garcia M 

PROVIDER: S-EPMC8694698 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature