Thymol derivatives with antibacterial and cytotoxic activity from the aerial parts of Ageratina adenophora.

ABSTRACT: Three new thymol derivatives, 7-formyl-9-isobutyryloxy-8-hydroxythymol (1), 7,9-di-isobutyryloxy-8,10-dehydrothymol (2) and 2α-methoxyl-3β-methyl-6-methylol-2,3-dihydrobenzofuran (3), along with five known ones (4-8), were isolated from the aerial parts of the invasive plant Ageratina adenophora. Their structures were elucidated by extensive spectroscopic analysis and they were all isolated from the aerial part of A. adenophora for the first time. These compounds, except 8, selectively showed in vitro antimicrobial activity against three Gram-(+) and two Gram-(-) bacterial strains. In particular, compounds 1 and 5 showed notable in vitro antimicrobial activity against all five bacterial strains with IC₅₀ values ranging from 3.9 to 15.6 μg mL^-1

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8694738 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature