Design and Synthesis of Tetrahydroisoquinoline Derivatives as Anti-Angiogenesis and Anti-Cancer Agents.

ABSTRACT:

Aim

The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer agents.

Background

Cancer is the second leading cause of deaths in the United States. The current recovery rate from the advanced treatment for the cancer is excessively low. Therefore, the identification of novel, potent, and less toxic anticancer agents remains a top priority.

Objective

To evaluate anti-angiogenesis and anticancer activities of THIQs on different colorectal cancer cell lines (CRC) viz., Colo320, DLD-1, HCT116, SNU-C1, SW480, and GSK3b in pre-treated viability HCT116. and to carry out molecular docking studies of THIQs.

Methods

Twenty synthesized THIQs were screened in the Eli Lilly's Open Innovation Drug Discovery Progr

SUBMITTER: Gangapuram M 

PROVIDER: S-EPMC8694809 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature