Synthesizing and evaluating the photodynamic efficacy of asymmetric heteroleptic A₇B type novel lanthanide bis-phthalocyanine complexes.

ABSTRACT: In this study heteroleptic A₇B type novel Lu(iii) and Eu(iii) lanthanide phthalocyanines (LnPc(Pox)[Pc'(AB₃SH)]) with high extinction coefficients have been synthesized as candidate photosensitizers with reaction yields higher than 33%. The singlet oxygen quantum yields of LuPc(Pox)[Pc'(AB₃SH)] and EuPc(Pox)[Pc'(AB₃SH)], respectively, were measured 17% and 1.4% by the direct method in THF. The singlet oxygen quantum yield of LuPc(Pox)[Pc'(AB₃SH)] in THF is the highest among lutetium(iii) bis-phthalocyanine complexes to date. The photodynamic efficacy of the heteroleptic lanthanide phthalocyanines was evaluated by measuring cell viabilities of A549 and BEAS-2B lung cells, selected to representing in vitro models for testing cance

SUBMITTER: Onal E 

PROVIDER: S-EPMC8694812 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature