Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products.

ABSTRACT: The syntheses and investigations of new biologically active derivatives of dihydropyrimidines by Biginelli reaction in the presence of copper triflate are reported. Due to the fact that salicylaldehyde and its derivatives under Biginelli reaction conditions can lead to the formation of 2 types of dihydropyrimidines, the influence of copper triflate on product formation was also investigated. In addition to this, regioselective oxidation of dihydropyrimidines was performed in the presence of cerium ammonium nitrate and novel oxidized dihydropyrimidines were obtained. Single crystals of some of them were obtained and as a result, the structures of them were investigated by X-ray diffraction method, which allows determining the presence of hydrogen bonds in their structures. In addition to th

SUBMITTER: Huseynzada AE 

PROVIDER: S-EPMC8694924 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature