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Novel synthesis of benzotriazolyl alkyl esters: an unprecedented CH₂ insertion.

ABSTRACT: We have developed a novel method for the synthesis of benzotriazolyl alkyl esters (BAEs) from N-acylbenzotriazoles and dichloromethane (DCM) under mild conditions. This reaction is one of few examples to show the use of DCM as a C-1 surrogate in carbon-heteroatom bond formation and to highlight the versatility of using DCM as a methylene building block.

SUBMITTER: Elagawany M

PROVIDER: S-EPMC8694985 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Novel synthesis of benzotriazolyl alkyl esters: an unprecedented CH2 insertion.

Elagawany Mohamed M Maram Lingaiah L Elgendy Bahaa B

RSC advances 20210217 13

We have developed a novel method for the synthesis of benzotriazolyl alkyl esters (BAEs) from N-acylbenzotriazoles and dichloromethane (DCM) under mild conditions. This reaction is one of few examples to show the use of DCM as a C-1 surrogate in carbon-heteroatom bond formation and to highlight the versatility of using DCM as a methylene building block. ...[more]

PMID: 35423285

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