Demonstration of sweat-based circadian diagnostic capability of SLOCK using electrochemical detection modalities.

ABSTRACT: SLOCK is a sweat-based circadian diagnostic platform used for mapping the user's chronobiology via cortisol and DHEA. In this work, we have demonstrated the detection capabilities of this sweat-based sensing platform using two electrochemical sensing modalities: Electrochemical Impedance Spectroscopy (EIS) and chronoamperometry. Wicking simulations for vertical versus horizontal flow patterns under potential bias were evaluated using COMSOL Multiphysics®. This work also highlights the biorecognition element characterization using Surface Plasmon Resonance (SPR) and FTIR. Sensor platform was evaluated for biomarker concentrations using doses spanning physiological ranges of 8-141 ng ml^-1 and 2-131 ng ml^-1 for cortisol and DHEA, respectively. Detailed anal

SUBMITTER: Upasham S 

PROVIDER: S-EPMC8695047 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature