Enhanced skin adhesive property of electrospun α-cyclodextrin/nonanyl group-modified poly(vinyl alcohol) inclusion complex fiber sheet.

ABSTRACT: Many medical tapes on the market lack sufficient adhesive strength and breathability. Owing to its high biocompatibility, poly(vinyl alcohol) (PVA), a synthetic polymer, has attracted attention in the medical field. In this study, we aimed to prepare an inclusion complex fiber (ICFiber) using α-cyclodextrin (α-CD) and nonanyl-group-modified PVA (C9-PVA) for skin adhesion with improved performance. By changing the concentration of α-CD, six microfiber sheets were fabricated by electrospinning the α-CD/2.3C9-PVA inclusion complex solutions. The bonding strength and energy of the ICFiber sheets on the porcine skin were evaluated. Among the tested ICFiber sheets, the ICFiber-3 (molar ratio of α-CD/C9 groups was 0.612) sheet showed high tensile strength and break strain. The bonding strength an

SUBMITTER: Chen X 

PROVIDER: S-EPMC8695218 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature