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Cobalt-catalyzed, directed arylation of C-H bonds in N-aryl pyrazoles.

ABSTRACT: We report a method for directed ortho-arylation of N-aryl pyrazoles with arylboronic acids. Reactions proceeded in the presence of a Co(hfacac)₂ catalyst, CeSO₄ oxidant, and HFIP solvent. Functionalities such as nitro, ester, bromo, and ketone groups were compatible with the reaction conditions. Using heterocycles including thiophene and carbazole was also feasible.

SUBMITTER: Nguyen TT

PROVIDER: S-EPMC8695287 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Cobalt-catalyzed, directed arylation of C-H bonds in N-aryl pyrazoles.

Nguyen Tung T TT Le Lam V LV Pham Hai H HH Nguyen Dung H DH Phan Nam T S NTS Le Ha V HV Phan Anh N Q ANQ

RSC advances 20210301 16

We report a method for directed ortho-arylation of N-aryl pyrazoles with arylboronic acids. Reactions proceeded in the presence of a Co(hfacac)2 catalyst, CeSO4 oxidant, and HFIP solvent. Functionalities such as nitro, ester, bromo, and ketone groups were compatible with the reaction conditions. Using heterocycles including thiophene and carbazole was also feasible. ...[more]

PMID: 35423432

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