Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection.

ABSTRACT: The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that leads to the formation of C5 convertase, thereby acting as a positive regulator of the alternative pathway. It has been noted that human properdin on its own can operate as a pattern recognition receptor and exert immune functions outside its involvement in complement activation. Properdin can bind directly to microbial targets via DNA, sulfatides and glycosaminoglycans, apoptotic cells, nanoparticles, and well-known viral virulence factors. This study was aimed at investigating the complement-independent role of properdin against I

SUBMITTER: Varghese PM 

PROVIDER: S-EPMC8695448 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature