The effect of interventions targeting gut microbiota on depressive symptoms: a systematic review and meta-analysis.

ABSTRACT:

Background

Despite their popularity, the efficacy of interventions targeting gut microbiota to improve depressive symptoms is unknown. Our objective is to summarize the effect of microbiome-targeting interventions on depressive symptoms.

Methods

We conducted a systematic review and meta-analysis. We searched MEDLINE, Embase, PsycINFO, Database of Abstracts of Reviews of Effects, Cochrane Database of Systematic Reviews and the Cochrane Controlled Register of Trials from inception to Mar. 5, 2021. We included studies that evaluated probiotic, prebiotic, synbiotic, paraprobiotic or fecal microbiota transplant interventions in an adult population (age ≥ 18 yr) with an inactive or placebo comparator (defined by the absence of active intervention). Studies must have measured depre

SUBMITTER: Hofmeister M 

PROVIDER: S-EPMC8695538 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature