Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.

ABSTRACT:

Introduction

Immune dysregulation is implicated in neurodegeneration and altered cytokine levels are seen in people with dementia. However, whether cytokine levels are predictive of cognitive decline in cognitively unimpaired (CU) elderly, especially in the setting of elevated amyloid beta (Aβ), remains unclear.

Methods

We measured nine cytokines in the baseline plasma of 298 longitudinally followed CU elderly and assessed whether these measures were associated with cognitive decline, alone or synergistically with Aβ. We next examined associations between cytokine levels and neuroimaging biomarkers of Aβ/tau/neurodegeneration.

Results

Higher IL-12p70 was associated with slower cognitive decline in the setting of higher Aβ (false discovery rate [FDR] = 0.0023), whereas

SUBMITTER: Yang HS 

PROVIDER: S-EPMC8695625 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature