MiRNA-mediated alteration of sulfatase modifying factor 1 expression using self-assembled branched DNA nanostructures.

ABSTRACT: Sulfatase enzymes catalyze sulfate ester hydrolysis, thus deficiencies of sulfatases lead to the accumulation of biomolecules resulting in several disorders. One of the important sulfatases is estrone sulfatase that converts inactive estrone sulfate to active estradiol. Posttranslational modification of highly conserved cysteine residue leads to unique formylglycine in the active site of sulfatases being critical for its catalytic activity. The essential factor responsible for this modification of sulfatase is Sulfatase-Modifying Factor 1 (SUMF1). The role of estrone sulfatase is well evident in breast cancer progression. However, the function and regulation of SUMF1 in cancer are not studied. In the present study, for the first time, we have assessed the expression of SUMF1 in breast canc

SUBMITTER: Kumari K 

PROVIDER: S-EPMC8695627 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature