Distinct Responses of Thitarodes xiaojinensis β-1,3-Glucan Recognition Protein-1 and Immulectin-8 to Ophiocordyceps sinensis and Cordyceps militaris Infection.

ABSTRACT: Melanization and encapsulation are prominent defense responses against microbes detected by pattern recognition receptors of their host insects. In the ghost moth Thitarodes xiaojinensis, an activated immune system can melanize and encapsulate the fungus Cordyceps militaris However, these responses were hardly detected in the host hemolymph postinfection of another fungus Ophiocordyceps sinensis The immune interaction between O. sinensis and the host remains largely unknown, which hinders the artificial cultivation of Chinese cordyceps. We found that T. xiaojinensis β-1,3-glucan recognition protein-1 (βGRP1) was needed for prophenoloxidase activation induced by C. militaris Failure of βGRP1 to recognize O. sinensis is a primary reason for th

SUBMITTER: Meng Q 

PROVIDER: S-EPMC8695634 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature