Microhematuria Enhances the Risks of Relapse and Renal Progression in Primary Membranous Nephropathy.

ABSTRACT: Objective: To determine whether there is an association between microhematuria and relapse or kidney disease progression in patients with primary membranous nephropathy (PMN). Methods: A cohort of 639 patients with biopsy-proven PMN from two centers was followed for a median of 40 months. The exposures were initial hematuria, time-averaged hematuria, and cumulative duration of hematuria. The outcomes were relapse and renal progression, which were defined by a 40% reduction in renal function or end-stage renal disease. Cox proportional hazards regression and competing risk analyses were performed to yield hazard ratios (HRs) and subdistribution hazard ratios (sHRs) with 95% confidence intervals (CIs). Sensitivity and interaction analyses were also performed. Results: Af

SUBMITTER: He P 

PROVIDER: S-EPMC8695761 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature