Location-Dependent DNA Methylation Signatures in a Clonal Invasive Crayfish.

ABSTRACT: DNA methylation is an important epigenetic modification that has been repeatedly implied in organismal adaptation. However, many previous studies that have linked DNA methylation patterns to environmental parameters have been limited by confounding factors, such as cell-type heterogeneity and genetic variation. In this study, we analyzed DNA methylation variation in marbled crayfish, a clonal and invasive freshwater crayfish that is characterized by a largely tissue-invariant methylome and negligible genetic variation. Using a capture-based subgenome bisulfite sequencing approach that covers a small, variably methylated portion of the marbled crayfish genome, we identified specific and highly localized DNA methylation signatures for specimens from geographically and ecologically distinct w

SUBMITTER: Tonges S 

PROVIDER: S-EPMC8695926 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature