Gastrointestinal Microbiota Changes in Patients With Gastric Precancerous Lesions.

ABSTRACT:

Background

Gastric microbiota may be involved in gastric cancer. The relationship between gastrointestinal microbes and the risk of gastric cancer is unclear. This study aimed to explore the gastric and intestinal bacteria associated with gastritis and gastric precancerous lesions. We conducted a case-control study by performing 16S rRNA gene analysis of gastric biopsies, juices, and stool samples from 148 cases with gastritis or gastric precancerous lesions from Anhui and neighboring provinces, China. And we validated our findings in public datasets.

Results

Analysis of microbial sequences revealed decreased bacterial alpha diversity in gastric bacteria during the progression of gastritis. Helicobacter pylori was the main contributor to the decreased microbial compos

SUBMITTER: Liu D 

PROVIDER: S-EPMC8695999 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature