Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening of Plasmodium falciparum.

ABSTRACT: The development of malaria vaccines and medicines depends on the discovery of novel malaria protein targets, but the functions of more than 40% of P. falciparum genes remain unknown. Asexual parasites are the critical stage that leads to serious clinical symptoms and that can be modulated by malaria treatments and vaccines. To identify critical genes involved in the development of Plasmodium parasites within erythrocytes, the expression profile of more than 5,000 genes distributed across the 14 chromosomes of the PF3D7 strain during its six critical developmental stages (merozoite, early-ring, late-ring, early trophozoite, late-trophozoite, and middle-schizont) was evaluated. Hence, a qRT-PCR-based transcriptome of the erythrocytic developmental process of P. falciparum

SUBMITTER: Hou N 

PROVIDER: S-EPMC8696357 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature