Modelling the impact of universal influenza vaccines on seasonal influenza with different subtypes.

ABSTRACT: Several candidates of universal influenza vaccine (UIV) have entered phase III clinical trials, which are expected to improve the willingness and coverage of the population substantially. The impact of UIV on the seasonal influenza epidemic in low influenza vaccination coverage regions like China remains unclear. We proposed a new compartmental model involving the transmission of different influenza subtypes to evaluate the effects of UIV. We calibrated the model by weekly surveillance data of influenza in Xi'an City, Shaanxi Province, China, during 2010/11-2018/19 influenza seasons. We calculated the percentage of averted infections under 2-month (September to October) and 6-month (September to the next February) vaccination patterns with varied UIV effectiveness and coverage in each infl

SUBMITTER: Li R 

PROVIDER: S-EPMC8697312 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature