Anti-Inflammatory Effects and Mechanisms of Pudilan Antiphlogistic Oral Liquid.

ABSTRACT: Pudilan antiphlogistic oral liquid (PDL) is a commercial traditional Chinese medicine widely used in the treatment of a variety of inflammatory diseases. However, the specific mechanisms of PDL's anti-inflammatory effects have not been fully understood. In this research, five classic inflammatory models and a network pharmacology-based strategy were utilized to evaluate its anti-inflammatory efficacy and elucidate its multicomponent and multitarget mode of the anti-inflammatory mechanism. A systems pharmacology approach was carried out via a holistic process of active compound screening, target acquisition, network construction, and further analysis. The potential component-target-associated anti-inflammatory mechanisms of PDL were further verified both in vivo and in vitr

SUBMITTER: Tian G 

PROVIDER: S-EPMC8697401 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature