Comprehensive serologic profile and specificity of maternal and neonatal cord blood SARS-CoV-2 antibodies.

ABSTRACT:

Background

Initial studies on COVID-19 in pregnancy have demonstrated a range of neutralizing activity, but little has been published on the full profile of SARS CoV-2 related antibodies in maternal and cordblood.

Objective

This study aimed to describe the profile and specificity of maternal and neonatal cord blood antibody profiles in response to SARS-CoV-2 virus exposure.

Study design

This was a prospective cohort study of delivering patients at Thomas Jefferson University Hospital from April 2020 to February 2021. The primary objective was to describe unique maternal and fetal antibody epitope titers and specificity in patients with COVID-19 history. Serologic profile was assessed with a multiplex platform. Antigens used were hemagglutinin trimer influenza A (Hong

SUBMITTER: Boelig RC 

PROVIDER: S-EPMC8697419 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature