Overnight variation in tidal expiratory flow limitation in COPD patients and its correction: an observational study.

ABSTRACT:

Background

Tidal expiratory flow limitation (EFL_T) is common among COPD patients. Whether EFL_T changes during sleep and can be abolished during home ventilation is not known.

Methods

COPD patients considered for noninvasive ventilation used a ventilator which measured within-breath reactance change at 5 Hz (∆Xrs) and adjusted EPAP settings to abolish EFL_T. Participants flow limited (∆Xrs > 2.8) when supine underwent polysomnography (PSG) and were offered home ventilation for 2 weeks. The EPAP pressure that abolished EFL_T was measured and compared to that during supine wakefulness. Ventilator adherence and subjective patient perceptions were obtained after home use.

Results

Of 26 patients with supine EFL_T, 15 compl

SUBMITTER: McKenzie J 

PROVIDER: S-EPMC8697433 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature