Poly (N-vinylpyrrolidone) modification mitigates plasma protein corona formation on phosphomolybdate-based nanoparticles.

ABSTRACT: Phosphomolybdate-based nanoparticles (PMo₁₂-based NPs) have been commonly applied in nanomedicine. However, upon contact with biofluids, proteins are quickly adsorbed onto the NPs surface to form a protein corona, which induces the opsonization and facilitates the rapid clearance of the NPs by macrophage uptake. Herein, we introduce a family of structurally homologous PMo₁₂-based NPs (CDS-PMo₁₂@PVP_x(x = 0 ~ 1) NPs) capping diverse content of zwitterionic polymer poly (N-vinylpyrrolidone) (PVP) to regulate the protein corona formation on PMo₁₂-based NPs. The fluorescence quenching data indicate that the introduction of PVP effectively reduces the number of binding sites of proteins on PMo₁₂-based NPs. Molecular docking simula

SUBMITTER: Yu Y 

PROVIDER: S-EPMC8697440 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature