Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes.

ABSTRACT:

Background

Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DNAm. It is unclear how overall metabolic health outside of BMI may modify the relationship between BMI and methylation profiles, and what consequences this may have on downstream cardiovascular disease. The purpose of this study was to identify cytosine-phosphate-guanine (CpG) sites at which the association between BMI and DNAm could be modified by overall metabolic health.

Results

The discovery study population was derived from three Women's Health Initiative (WHI) ancillary studies (n = 3977) and two Atherosclerosis Risk in Communities (ARIC) ancillary studi

SUBMITTER: Do WL 

PROVIDER: S-EPMC8697469 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature