COVID-19 Vaccination Effectiveness Against Infection or Death in a National U.S. Health Care System : A Target Trial Emulation Study.

ABSTRACT:

Background

Little is known about real-world COVID-19 vaccine effectiveness (VE) in racially and ethnically diverse, elderly populations with high comorbidity burden.

Objective

To determine the effectiveness of messenger RNA COVID-19 vaccines.

Design

Target trial emulation study comparing newly vaccinated persons with matched unvaccinated controls.

Setting

U.S. Department of Veterans Affairs health care system.

Participants

Among persons receiving care in the Veterans Affairs health care system (n = 5 766 638), those who received at least 1 dose of the Moderna or Pfizer-BioNTech COVID-19 vaccine from 11 December 2020 to 25 March 2021 (n = 2 099 871) were matched to unvaccinated controls in a 1:1 ratio according to demographic, clinical, and

SUBMITTER: Ioannou GN 

PROVIDER: S-EPMC8697485 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature