Closed-Loop Multiscale Computational Model of Human Blood Circulation. Applications to Ballistocardiography.

ABSTRACT: Cardiac mechanical activity leads to periodic changes in the distribution of blood throughout the body, which causes micro-oscillations of the body's center of mass and can be measured by ballistocardiography (BCG). However, many of the BCG findings are based on parameters whose origins are poorly understood. Here, we generate simulated multidimensional BCG signals based on a more exhaustive and accurate computational model of blood circulation than previous attempts. This model consists in a closed loop 0D-1D multiscale representation of the human blood circulation. The 0D elements include the cardiac chambers, cardiac valves, arterioles, capillaries, venules, and veins, while the 1D elements include 55 systemic and 57 pulmonary arteries. The simulated multidimensional BCG signal is compu

SUBMITTER: Rabineau J 

PROVIDER: S-EPMC8697684 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature