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Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides.

ABSTRACT: Herein, direct alkylation of the C-H bond at the α-position of furans catalyzed by palladium catalyst is reported. This protocol targets α-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry.

SUBMITTER: Yuan J

PROVIDER: S-EPMC8697702 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides.

Yuan Jiaqi J Zhang Xiaofei X Yang Chunhao C

RSC advances 20210414 23

Herein, direct alkylation of the C-H bond at the α-position of furans catalyzed by palladium catalyst is reported. This protocol targets α-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry. ...[more]

PMID: 35423913

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