Ultrasmall copper nanoclusters with multi-enzyme activities.

ABSTRACT: Reactive oxygen species (ROS) as a key messenger of signal transduction mediate physiological activities, however, oxidative stress produced by excessive ROS can cause the destruction of cell homeostasis, which will result in a series of diseases. Therefore, effective control of ROS level is critical to the homeostasis of the cell. Here, we reported that glutathione (GSH)-stabilized copper nanoclusters (CuNCs) with about 9 Cu atoms can functionally mimic three major antioxidant enzymes, namely catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD). The rate of H₂O₂ decomposition was calculated to be ∼0.23 mg L^-1 s^-1 when the concentration of CuNCs was 100 μg mL^-1. The SOD-like activity by catalyzing the disproporti

SUBMITTER: Peng Y 

PROVIDER: S-EPMC8697926 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature