Ion Channel and Ubiquitin Differential Expression during Erythromycin-Induced Anhidrosis in Foals.

ABSTRACT: Macrolide drugs are the treatment of choice for Rhodococcus equi infections, despite severe side-effects temporary anhidrosis as a. To better understand the molecular biology leading to macrolide induced anhidrosis, we performed skin biopsies and Quantitative Intradermal Terbutaline Sweat Tests (QITSTs) in six healthy pony-cross foals for three different timepoints during erythromycin administration-pre-treatment (baseline), during anhidrosis and post-recovery. RNA sequencing of biopsies followed by differential gene expression analysis compared both pre and post normal sweating timepoints to the erythromycin induced anhidrosis episode. After Bonferroni correction for multiple testing, 132 gene transcripts were significantly differentially expressed during the anhidrotic timepoint.

SUBMITTER: Patterson Rosa L 

PROVIDER: S-EPMC8697959 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature