Utero-Placental Immune Milieu during Normal and Aglepristone-Induced Parturition in the Dog.

ABSTRACT: Maternal immunotolerance is required for the maintenance of pregnancy, in sharp contrast with the uterine pro-inflammatory activity observed during parturition in several species. Correspondingly, in the dog, increased immune signaling at term has been suggested, but a deeper understanding of the uterine immune milieu is still missing. Thus, the availability of 30 immune-related factors was assessed in utero-placental samples collected during post-implantation (days 18-25 of pregnancy) and mid-gestation (days 35-40) stages, and at the time of prepartum luteolysis. Gene expression and/or protein localization studies were employed. Samples collected from antigestagen (aglepristone)-treated dogs were further analyzed. Progression of pregnancy was associated with the downregulation of IL1β and

SUBMITTER: Tavares Pereira M 

PROVIDER: S-EPMC8697996 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature