Dual Control of Peptide Conformation with Light and Metal Coordination.

ABSTRACT: The design of a stimuli-responsive peptide whose conformation is controlled by wavelength-specific light and metal coordination is described. The peptide adopts a defined tertiary structure and its conformation can be modulated between an α-helical coiled coil and β-sheet. The peptide is designed with a hydrophobic interface to induce coiled coil formation and is based on a recently described strategy to obtain switchable helix dimers. Herein, we endowed the helix dimer with 8-hydroxyquinoline (HQ) groups to achieve metal coordination and shift to a β-sheet structure. It was found that the conformational shift only occurs upon introduction of Zn²⁺ ; other metal ions (Cu²⁺ , Fe³⁺ , Co²⁺ , Mg² , and Ni²⁺ ) do not offer switchi

SUBMITTER: Ghosh P 

PROVIDER: S-EPMC8698214 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature